Kymab Presents Updates at the American Society of Hematology (ASH) 61st Annual Meeting and Exposition
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Kymab Presents Updates at the American Society of Hematology (ASH) 61st Annual Meeting and Exposition
Cambridge, UK; December 6, 2019: Kymab, a clinical-stage biopharmaceutical company developing monoclonal and bispecific antibody-based therapeutics, today announced that abstracts describing two lead hematology programs, KY1049 and KY1066, will be presented at the American Society of Hematology 61st Annual Meeting and Exposition, being held December 7-10, 2019 in Orlando, Florida. The presentations will include posters highlighting preclinical data from these portfolio programs: KY1049 (a fully-human FVIII-mimetic common light chain bispecific antibody) and KY1066 (a fully-human antibody against matripase-2 for the treatment of iron overload in anemia).
Poster presentation details are as follows:
Title: 2410 - A Fully Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency Ex Vivo
Date and Time: Sunday, December 8, 2019, 6:00-8:00 p.m. ET
Session: 322. Disorders of Coagulation or Fibrinolysis: Poster II
Location: Hall B, Level 2, Orange County Convention Center
Presenter: John Blackwood, Ph.D., Senior Research Scientist
Background:
Title: 3532 - Generation and Characterization of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta-Thalassemia
Date and Time: Monday, December 9, 2019, 6:00-8:00 p.m. ET
Session: 102. Regulation of Iron Metabolism: Poster III
Location: Hall B, Level 2, Orange County Convention Center
Presenter: Matthew Wake, Ph.D. Research Scientist
Background:
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NOTES TO EDITORS
About KY1049
KY1049 is a fully human common light-chain bispecific antibody discovered using the IntelliSelect® Bispecifics platform – part of Kymab’s IntelliSelect® Suite of technologies. KY1049 simultaneously binds coagulation Factor IXa (F.IXa) and Factor X (F.X) on the surface of platelets, bringing both factors into close proximity. This coincident binding stimulates the F.IXa catalyzed activation of F.X resulting in restoration of the coagulation cascade in the absence of Factor VIII.
Hemophilia A is an X-linked recessive genetic disorder resulting in a deficiency of Factor VIII and whose symptoms include increased bleeding and reduced blood clotting. KY1049 has been tested in plasma samples from severe Hemophilia A patients (with and without inhibitors) and can reproducibly restore homeostatic function as measured using clinically validated methods such as clotting time (aPTT - activated partial thromboplastin time) and thrombin generation.
About KY1066
KY1066 is fully human IgG4 antibody discovered using Kymab’s IntelliSelect® Suite of technologies. A lead panel was identified by functionally screening for enzymatic inhibition of matriptase-2 and in vivo testing in healthy mice and rats. Selected leads are being tested in a model of beta-thalassemia, one of the potential indications for this antibody.
About Kymab
Kymab is a clinical-stage biopharmaceutical company developing a deep pipeline of novel antibody-based therapies in a broad range of indications. The Company generates its product candidates using its proprietary, integrated platforms collectively called IntelliSelect®. Kymab’s platforms have been designed to maximize the diversity of human antibodies produced in response to immunization with antigens. Selecting from a broad diversity of fully human antibodies allows for the identification of antibodies with optimal drug-like properties.
For more information on Kymab please see http://www.kymab.com.
About IntelliSelect® Bispecifics
The IntelliSelect® Bispecifics platform is designed to generate fully-human bispecific antibodies with naturally-paired common light chains. The platform relies on highly-engineered strains of mice that have the complete constellation of human antibody diversity for the antibody heavy chain and one or more selected light chains.
The IntelliSelect® Bispecifics platform combines single cell sequencing, genomics and proprietary bioinformatic algorithms to prioritize and select antibodies that have the most desirable drug-like properties.
For more information please see http://www.kymab.com. Kymab and IntelliSelect® are registered trademarks of Kymab Limited.
Forward-looking statements
This announcement includes forward-looking statements that involve risks, uncertainties and other factors, many of which are outside of our control, that could cause actual results to differ materially from the results discussed in the forward-looking statements. Forward-looking statements include statements concerning our plans, objectives, goals, future events, performance and/or other information that is not historical information. All such forward-looking statements are expressly qualified by these cautionary statements and any other cautionary statements which may accompany the forward-looking statements. We undertake no obligation to publicly update or revise forward-looking statements to reflect subsequent events or circumstances after the date made, except as required by law.
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