Sapience Therapeutics Announces Multiple Posters, Including Late-Breaker, at the American Association for Cancer Research (AACR) Annual Meeting 2021

Tags:   Preclinical   Phase 1   Oncology   Breast Cancer   AACR  

-Late-breaking poster with clinical update from ongoing Phase 1 study of ST101-

-Two additional posters on preclinical results of ST101 in breast cancer and BCAP program-

HARRISON, N.Y., April 6, 2021 /PRNewswire/ -- Sapience Therapeutics, Inc., a clinical stage biotechnology company focused on the discovery and development of peptide therapeutics to address difficult to treat oncology indications, today announced multiple poster presentations, including a late-breaker, at the American Association for Cancer Research (AACR) Annual Meeting 2021, which is being held in a virtual format. The posters will be available on April 10, 2021.  

Details of the poster presentations are as follows:

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Title: Tumor uptake and predictable PK of ST101 - a peptide antagonist of C/EBPβ - in patients with advanced unresectable and metastatic solid tumors Abstract Control Number: 5106Presentation Time: The e-poster will be available on the AACR website on Saturday, April 10, 2021Session Type: E-Poster Session (late-breaker)Session Category: Experimental and Molecular Therapeutics Session Title: New TargetsPermanent Abstract Number: LB114

Title:  C/EBPβ antagonist peptide, ST101, as a therapeutic approach in breast cancerAbstract Control Number:  3578Presentation Time: The e-poster will be available on the AACR website on Saturday, April 10, 2021Session Type: E-Poster SessionSession Category:  Experimental and Molecular TherapeuticsSession Title: Biological Therapeutic AgentsPermanent Abstract Number: 959

Title:  β-catenin antagonist peptide attenuates Wnt-dependent oncogenic activityAbstract Control Number:  3677Presentation Time: The e-poster will be available on the AACR website on Saturday, April 10, 2021Session Type: E-Poster SessionSession Category: Experimental and Molecular TherapeuticsSession Title: Biological Therapeutic AgentsPermanent Abstract Number: 964

More details can be found at https://www.aacr.org/meeting/aacr-annual-meeting-2021/.

About ST101

ST101 is a peptide inhibitor of C/EBPβ, which is a transcription factor overexpressed in many cancers that regulate cellular differentiation and promote tumor survival and proliferation. ST101 significantly decreases the expression of C/EBPβ target genes/proteins involved in cell survival, proliferation and differentiation including BCL-2, MCL-1, BIRC5/survivin, cyclins and ID family of proteins. ST101 has been demonstrated to induce selective cancer cell cytotoxicity across a variety of tumor types, including but not limited to breast cancer, melanoma, prostate cancer, GBM, lung cancer, and AML. C/EBPβ is expressed and active in cancer cells but not active in normal cells (post-differentiation), providing a therapeutic opportunity.

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About Sapience Therapeutics

Sapience Therapeutics, Inc., is a privately held, clinical stage biotechnology company focused on discovering and developing peptide-based therapeutics for major unmet medical needs, particularly high mortality cancers. With platform-based discovery of peptide therapeutics that disrupt protein-protein interactions, Sapience's molecules hold potential to target intracellular interactions that are traditionally considered "undruggable targets". Its lead compound, ST101, is a first-in-class molecule with potential applications in various solid tumors and hematologic malignancies.  Sapience is headquartered in Harrison, New York.  For more information on Sapience Therapeutics, please visit www.sapiencetherapeutics.com and engage with us on LinkedIn.

Cautionary Note on Forward-Looking Statements

This press release contains forward-looking statements. Any statements herein other than statements of historical fact could be deemed to be forward-looking statements. These forward-looking statements may include, among other things, statements regarding future events that involve significant risks and uncertainties (including with respect to Sapience's preclinical and clinical development programs). These forward-looking statements are based on management's current expectations, and actual results and future events may differ materially as a result of certain factors, including, without limitation, risks related to the application of the net proceeds from the offering to Sapience's product development objectives, our ability to obtain additional funds, and meet applicable regulatory standards and receive required regulatory approvals. Forward-looking statements speak only as of the date of this press release. Sapience does not undertake any obligation to update any forward-looking statements as a result of new information, future events, changed assumptions or otherwise, except as required by law.

Media and Investor Contact:

Amy ConradJuniper Point(858) 366-3243[email protected]

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