Ankyra is developing a platform to significantly improve both the safety and efficacy of cytokine immunotherapies for cancer. Systemic dosing of these powerful immune stimulants is severely limited by unintended activation of irrelevant bystander cells in circulation. We have developed methods to localize cytokines specifically and persistently within tumor tissue, creating intense hot spots of inflammation that awaken an anti-tumor immune response. We are translating this approach for the treatment of solid tumors.