Catamaran Bio Presents Preclinical Efficacy Data for Two Allogeneic CAR-NK Cell Therapies for Solid Tumors at SITC 2022 Annual Meeting
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Preclinical
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Catamaran Bio, Inc., a biotechnology company developing off-the-shelf NK cell therapies to treat cancer, today announced new data demonstrating preclinical efficacy of two CAR-NK cell therapies in solid and hematological cancers. The data are being presented in two posters at the Society for Immunotherapy in Cancer (SITC) 37th Annual Meeting, being held in Boston, Massachusetts, November 8-12, 2022.
“Collectively, these preclinical data sets demonstrate the power of Catamaran’s fully-integrated TAILWIND™ platform to deliver allogeneic NK cell therapies for solid tumors,” said Vipin Suri, PhD, MBA, Chief Scientific Officer of Catamaran Bio. “We have now shown preclinical efficacy in multiple xenograft models with two differentiated CAR-NK cell therapies engineered with the functional attributes necessary for durable efficacy in solid tumors and manufactured using an efficient non-viral cell engineering system.”
Data supporting Catamaran’s lead program, CAT-248, will be presented in a poster titled “Engineering CD70-directed CAR-NK cells for the Treatment of Hematological and Solid Malignancies.” Highlights include:
These results demonstrate the potential for targeting CD70 with CAR-NK cell therapy for the treatment of AML, RCC, and other CD70-positive malignancies while overcoming fratricide issues by engineering with a non-viral transposon delivery system in combination with CRISPR/Cas9 editing.
Data from a second CAR-NK cell therapy construct engineered using the TAILWIND™ platform are presented in a poster titled “Allogeneic Natural Killer Cells Engineered to Express HER2-directed CAR, Interleukin-15 and TGFβ Dominant Negative Receptor Effectively Control HER2+ Tumors.” Highlights include:
These results demonstrate that NK cells engineered via the TAILWIND™ platform have a favorable pharmacologic profile and the potential for treatment of solid tumors.
Both posters are available on the Catamaran Bio website.
About Catamaran Bio
Catamaran Bio is developing novel, off-the-shelf chimeric antigen receptor (CAR)-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Our team combines experienced biopharmaceutical leadership with founding scientists who are pioneers in NK cell biology, engineering, manufacturing and clinical application. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures, Astellas Venture Management, and the UMN Discovery Capital investment program. For more information, please visit www.catamaranbio.com and follow us on LinkedIn and @CatamaranBio on Twitter.
Contacts
Catamaran Contact: Mark Boshar, Chief Operating Officer 617-620-9709 mark@catamaranbio.com
Media Contact: Kathryn Morris, The Yates Network 914-204-6412 kathryn@theyatesnetwork.com
Catamaran Contact: Mark Boshar, Chief Operating Officer 617-620-9709 mark@catamaranbio.com
Media Contact: Kathryn Morris, The Yates Network 914-204-6412 kathryn@theyatesnetwork.com
