Philogen Provides Corporate Update
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Philogen Provides Corporate Update
Siena (Italy), December. 1, 2022 - Philogen S.p.A. (BIT:PHIL), a clinical-stage biotech company focused on the development of innovative medicines based on tumor targeting antibody and small molecule ligands, is pleased to provide an update on its RandD programs.
Dario Neri, co-founder, CEO and CSO of Philogen, commented: "We are very pleased with the recent progress of our pipeline. We currently have seven pivotal clinical trials underway with Nildegy™ and Fibromun for which we expect important readouts in the coming years. Our most advanced study is the one of Nidlegy™ in stage IIIB,C melanoma and we expect to reach 95 events to complete the trial in 2023.
Based on the complete remissions being observed with Nidlegy™ in high-risk Basal Cell Carcinoma (BCC), the Company is committed to expand the number of clinical centers to speed up timelines. It is important to highlight that the market potential in high-risk BCC is potentially larger than the melanoma market. We have the ambition to turn Nidlegy™ into a broad applicable dermato-oncology drug.
Fibromun’s registration studies remain on track, both in Soft Tissue Sarcoma and in Glioblastoma.
Our Discovery Center has been very productive, having published more than 15 scientific peer reviewed publications and has initiated two novel collaborations with Bracco imaging and Janssen which are currently ongoing.
Our Group is increasing its investments in the discovery of small molecule tumor-targeting agents, which may facilitate the selective delivery of therapeutic radionuclides (Small Molecule Radiolabeled Conjugates, or “SMRCs”) and of non-radioactive drugs (Small Molecule Drug Conjugates, or “SMDCs”). The excellent targeting properties of our OncoFAP small molecule ligand bode well for delivering both therapeutic radionuclides and cytotoxic drugs to tumors. Stimulated by curative activity observed in “difficult-to-treat” preclinical models of cancer, preparation activities for therapeutic trials with the OncoFAP platform are ongoing.”
MAIN EVENTS AND RECENT HIGHLIGHTS
The Group remains engaged in the strengthening of its in-house RandD, as well as contractual activities related to discovery and/or manufacturing. It also runs Business Development activities with potential industrial partners in order to seek new scientific collaborations on an opportunistic basis.
PHILOGEN GROUP DESCRIPTION
Philogen is an Italian-Swiss company active in the biotechnology sector, specialized in the research and development of pharmaceutical products for the treatment of highly lethal diseases. The Group mainly discovers and develops targeted anticancer drugs, exploiting high-affinity ligands for tumor markers (also called tumor antigens). These ligands - human monoclonal antibodies or small organic molecules - are identified using Antibody Phage Display Libraries and DNA-Encoded Chemical Library technologies.
The Group's main therapeutic strategy for the treatment of these diseases is represented by the so-called tumor targeting. This approach is based on the use of ligands capable of selectively delivering very potent therapeutic active ingredients (such as pro-inflammatory cytokines) to the tumor mass, sparing healthy tissues. Over the years, Philogen has mainly developed monoclonal antibody-based ligands that are specific for antigens expressed in tumor-associated blood vessels, but not expressed in blood vessels associated with healthy tissues. These antigens are usually more abundant and more stable than those expressed directly on the surface of tumor cells. This approach, so called vascular targeting, is used for most of the projects pursued by the Group.
The Group's objective is to generate, develop and market innovative products for the treatment of diseases for which medical science has not yet identified satisfactory therapies. This is achieved by exploiting (i) proprietary technologies for the isolation of ligands that react with antigens present in certain diseases, (ii) experience in the development of products targeted at the tissues affected by the disease, (iii) experience in drug manufacturing and development, and (iv) an extensive portfolio of patents and intellectual property rights.
Although the Group's drugs are primarily oncology applications, the targeting approach is also potentially applicable to other diseases, such as certain chronic inflammatory diseases.
FOR MORE INFORMATION:
Philogen - Investor Relations
IR@philogen.com - Emanuele Puca | Investor Relations
Consilium Strategic Communications contacts
Mary-Jane Elliott, Davide Salvi
Philogen@consilium-comms.com
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